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KMID : 0382319900100020093
Environmental Mutagens and Carcinogens
1990 Volume.10 No. 2 p.93 ~ p.106
A Novel Behavior , Bang-Sensitive Paralysis , Associated With The shibire Locus of Drosophila melanogaster

Abstract
The Drosophila temperature-sensitive mutant shibire (shi) is paralyzed at restrictive temperature by a reversible block in synaptic transmission. To explore the functional relationship among shi gene products, viability and temperature-sensitive paralytic behavior were quantitaively analyzed for four shi alleles, shits1, shits2, shits4, and shiST139, and their heteroallelic combinations. The hemizygous combination of shi alleles over deficiency was not completely lethal. shits2 exhibited distinctively higher viability than other alleles.
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